✦ LIBER ✦
Using Molecular Symmetry to Form New Drugs: Hydroxymethyl-Substituted 3,9-Diazatetraasteranes as the First Class of Symmetric MDR Modulators
✍ Scribed by Andreas Hilgeroth; Jósef Molnár; Eric De Clercq
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 79 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
✦ Synopsis
Scheme 1. Synthesis of the monomeric 4-aryl-1,4-dihydropyridines. a) CuI (5 mol %), ROCOCl (1 equiv), 10 min, À8 8C, THF; b) PhMgCl (1 equiv), 30 min, RT, 1 a (75 %), 1 b (83 %); c) tBuOK (2 equiv), 30 min, À18 8C, THF, 1 c (69 %).