𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Using metabolomic analysis to understand inflammatory bowel diseases

✍ Scribed by Hui-Ming Lin; Nuala A. Helsby; Daryl D. Rowan; Lynnette R. Ferguson

Book ID
102267753
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
112 KB
Volume
17
Category
Article
ISSN
1078-0998

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✦ Synopsis

Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) attributed to a dysregulated immune response towards intestinal microbiota. Although various susceptibility genes have been identified for CD and UC, the exact disease etiology is unclear and complicated by the influence of environmental factors. Metabolomic analysis enables high sample throughput measurements of multiple metabolites in biological samples. The use of metabolomic analysis in medical sciences has revealed metabolite perturbations associated with diseases. This article provides a summary of the current understanding of IBD, and describes potential applications and previous metabolomic analysis in IBD research to understand IBD pathogenesis and improve IBD therapy.

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