Using information from both parents when testing for association between marker and disease loci

✍ Scribed by J.C. Whittaker; A.P. Morris; R.N. Curnow

• Book ID: 101263685
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 59 KB
• Volume: 15
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/(sici)1098-2272(1998)15:2<193::aid-gepi7>3.0.co;2-7

✦ Synopsis

Several extensions of the transmission/disequilibrium test (TDT) to multi-allelic markers now exist. In some of these, however, separate tests must be performed on male and female parents because of the non-independence of parental transmission patterns, reducing power, and complicating interpretation of the test results. Here we show that this non-independence is asymptotically irrelevant when using the allelic TDT of Bickeböller and Clerget-Darpoux [(1995) Genet