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A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis

✍ Valerie S. Calvert; Rochelle Collantes; Hazem Elariny; Arian Afendy; Ancha Baran 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 929 KB

Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Omental adipose tissue, a biologically active organ secreting adipokines and cytokines, may play a role in the development of NAFLD. We tested this hypothesis with reverse-phase protein microarrays (RPA) for multipl