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Usefulness of cytosine arabinoside (NSC-63878) and prednisone (NSC-10023) in refractory childhood lymphoblastic leukemia

✍ Scribed by Nesbit, Mark E. ;Sonley, Marilyn ;Hammond, Denman

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
366 KB
Volume
2
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

One hundred forty‐three children with refractory lymphoblastic and undifferentiated leukemia (ALL/AUL) were treated with cytosine arabinoside (Ara‐C) and prednisone (Pred). The dose and duration of Ara‐C was escalated during induction depending on the response seen in the peripheral blood and/or bone marrow. For those achieving a remission, Ara‐C was also used to determine its maintenance capabilities. Of the 143 children, 79 attained a clinical remission, 45 having a complete bone marrow remission and 34 having a partial remission. Maintenance of remission with twice weekly Ara‐C was short and did not appear to depend on the amount of Ara‐C given during induction. The major toxicity of Ara‐C was myelosuppression.

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