Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma
✍ Scribed by Ruoh-Fang Yen; Lai-Lei Ting; Mei-Fang Cheng; Yen-Wen Wu; Kai-Yuan Tzen; Ruey-Long Hong
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 199 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1043-3074
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✦ Synopsis
Abstract
Background
This study was designed to compare ^201^Tl single photon emission computed tomography (SPECT)/CT with 18‐fluoro‐2‐deoxyglucose (^18^F‐FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).
Methods
Twenty‐seven patients were recruited. Both ^201^Tl SPECT/CT and ^18^F‐FDG PET/CT for each patient were performed at least 4 months later after initial therapy.
Results
The sensitivity and specificity for ^201^Tl SPECT/CT were 66.7% and 100%, and those for ^18^F‐FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.
Conclusion
^201^Tl SPECT/CT is as effective as ^18^F‐FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, ^201^Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than ^18^F‐FDG PET. © 2009 Wiley Periodicals, Inc. Head Neck, 2009