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Use of tumor-specific promoter for experimental gene therapy in small cell lung carcinoma

โœ Scribed by Inase, N; Yoshizawa, Y

Book ID
118570241
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
118 KB
Volume
29
Category
Article
ISSN
0169-5002

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Use of gastrin-releasing peptide promote
Use of gastrin-releasing peptide promoter for specific expression of thymidine kinase gene in small-cell lung carcinoma cells
โœ Naohiko Inase; Kouichi Horita; Michiko Tanaka; Shuji Miyake; Masahiko Ichioka; Y ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 89 KB

For specific transduction of herpes simplex virus thymidine kinase (HSV-tk) into human small-cell lung carcinoma (SCLC) cells, we explored the 5'-flanking region (-1.1 kb) of the gastrin-releasing peptide (GRP) gene as a lung cancer-specific promoter. RT-PCR analysis demonstrated expression of GRP m