Use of the elevated plus-maze and social interaction tests as rodent models of anxiety: Ontogeny, pitfalls and lessons learned

Lack of effects of 5HT3receptor antagoni

Lack of effects of 5HT3receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

✍ Sandra E. File; Amanda L. Johnston 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 463 KB

The effects of three 5HT3 receptor antagonists: BRL 43964 (0.1 and 1 mg/kg, oral), GR 38032F (0.1 and 1 mg/kg, oral), and zacopride (0.01, 0.1 and 1 mg/kg, IP) were examined in low light test conditions of the social interaction test. None of the three 5HT3 receptor antagonists had a significant eff