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Use of the carbopalladation of 1,2-propadiene in a two step synthesis of steroids

✍ Scribed by Véronique Gauthier; Bernard Cazes; Jacques Gore

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
239 KB
Volume
32
Category
Article
ISSN
0040-4039

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✦ Synopsis

ESCLL Abstrru;f. The palladium-catalyzed reaction of 12-propadiene , the enol triflate of an atetralone and the enolate of 2-methyl-1,3-cyclopentanedione leads to compounds such as b which are transformed under acidic conditions to steroidal trienones. This approach to the steroid skeleton is presently hrnited to compounds having an aromatic A-ring.

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