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Use of sulfur derivatives as an ortho directing group for the metalation of diazines. Metalation of diazines. XVIII

✍ Scribed by Alain Turck; Nelly Plé; Paméla Pollet; Ljubica Mojovic; Jack Duflos; Guy Quéguiner

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
547 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The metalation of thioethers, methyl and phenyl sulfoxides and sulfones of pyrazine and pyridazine has been performed. Methyl sulfoxides and sulfones were first metalated on the methyl group. The ortho directing effect of thioethers, sulfoxides and sulfones have been compared with the methoxy group. The sulfoxides were shown to be very good ortho directing groups.

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