Use of small diameter WCOT columns for ultra-high resolution GC/MS

✍ Scribed by Hyver, K. J.

• Book ID: 102349548
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 321 KB
• Volume: 11
• Category: Article
• ISSN: 0935-6304
• DOI: 10.1002/jhrc.1240110118

✦ Synopsis

For clinical and environmental analyses utilizing capillary gas chromatography/mass spectrometry (GC/MS), increased sensitivity and speed of analysis are highly desirable. These performance advantages are realized using a WCOT column of 100 pm i.d. as compared to the more conventional 200 pm i.d. capillary columns. The improved sensitivity of capillary direct G U M S with the 100 pm i.d. column for the confirmation of drugs of abuse will be demonstrated. For environmental analysis, the superior efficiency and resolution of the 100 pm i.d. column can be employed for the separation of priority pollutants. This approach is more amenable to capillary direct GC/MS providing a more effective interface to the mass spectrometer. As a result improved sensitivity and a considerable decrease in analysis time is achieved over that obtained with the larger diameter environmental specialty phase columns.