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Use of Robust Classification Techniques for the Prediction of Human Cytochrome P450 2D6 Inhibition

✍ Scribed by Susnow, R.G.; Dixon, S.L.

Book ID: 120023984
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 265 KB
Volume: 43
Category: Article
ISSN: 0095-2338
DOI: 10.1021/ci030283p

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## Abstract The human cytochrome P450 2B6 can metabolize a number of clinical drugs. Inhibition of CYP2B6 by coadministered multiple drugs may lead to drug–drug interactions and undesired drug toxicity. The aim of this investigation is to develop an __in silico__ model to predict the interactions b