Use of regulated secretion in protein production from animal cells: An evaluation with the AtT-20 model cell line

Knockdown of amyloid precursor protein n

Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome

✍ Patricia Opazo; Katherine Saud; Michelle de Saint Pierre; Ana María Cárdenas; Da 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 307 KB

## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin