Use of radiation therapy in posttransplant lymphoproliferative disorder (PTLD) after liver transplantation

✍ Scribed by B.H. Koffman; A.S. Kennedy; M. Heyman; J. Colonna; C. Howell

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: French
• Weight: 328 KB
• Volume: 90
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(20000420)90:2<104::aid-ijc6>3.0.co;2-0

✦ Synopsis

Posttransplant lymphoproliferative disorder (PTLD) is a common and lifethreatening complication of immunosuppression used to prevent rejection of solid organ and bone marrow transplants.

There is no standardized treatment algorithm, but numerous management strategies are available. We describe a patient who developed a solitary lymphoproliferative lesion in the porta hepatis 9 months after orthotopic liver transplant. Following reduction in immunosuppression with no response, she was treated with involved field radiotherapy utilizing CT-based treatment planning. A partial radiographic response was obtained, and she has not developed disease in the engrafted liver or systemically. Based on the present case report, involved field radiotherapy seems to be a reasonable treatment option for patients with localized PTLD.