Use of protic and aprotic solvents of high volatility as matrices in analytical low-temperature fast-atom bombardment mass spectrometry
✍ Scribed by J. H. Gross
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 111 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0951-4198
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✦ Synopsis
Low-temperature fast-atom bombardment mass spectrometry (LT-FAB-MS) can extend the range of applications of FAB-MS significantly. Solvents of high volatility, either protic or aprotic, can be used as matrices for FAB-MS. For this purpose, the solution of the analyte in the respective solvent is frozen in liquid nitrogen on the FAB probe tip prior to measurement. Thus, one important limitation for selecting the FAB matrix is circumvented. Instead, solvent characteristics optimized to meet the requirements of the analyte are becoming the crucial parameter for the matrix of choice. The potential of this method of sample preparation is demonstrated by the use of methanol as a matrix for LT-FAB-MS of g-cyclodextrin, dichloromethane for porphyrins and a ruthenium carbonyl-porphyrin complex and toluene for [60]fullerene.