✦ LIBER ✦

Use of photodynamic therapy for the management of pleural malignancies

✍ Scribed by Harvey I. Pass; Jessica S. Donington

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 819 KB
Volume: 11
Category: Article
ISSN: 8756-0437
DOI: 10.1002/ssu.2980110506

No coin nor oath required. For personal study only.

✦ Synopsis

Photodynamic therapy (PDT) is a surface oriented, locally cytotoxic intervention being investigated for oncologic therapy. Surfaces such as the pleura or the peritoneum are frequently involved with primary or metastatic cancer, and the chance for cure in such situations is low due to the inability to eradicate all the disease. A series of investigations have been performed at the National Cancer Institute since 1985 studying the possible use of PDT for large cavity treatment. This report details evolution of the methodology, toxicity, and overall feasibility of the delivery of intrapleural PDT to patients after debulking of primary and malignant chest neoplasms, with an emphasis on malignant pleural mesothelioma. These investigations have culminated in an ongoing Phase I11 trial to define the efficacy of intrapleural PDT.

📜 SIMILAR VOLUMES

Intraoperative photodynamic therapy of t

Intraoperative photodynamic therapy of the chest cavity in malignant pleural mesothelioma bearing rats

✍ Thorsten Krueger; Youmin Pan; Nam Tran; Hans-Joerg Altermatt; Isabelle Opitz; Ha 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB

## Abstract ## Background and Objective Experimental assessment of anticancer effect, normal tissue damage, and toxicity of intrathoracic mTHPC‐mediated photodynamic therapy (PDT) combined to surgery in malignant pleural mesothelioma (MPM) bearing rats. ## Study Design/Materials and Methods Six

Photodynamic therapy for treatment of ma

Photodynamic therapy for treatment of malignant cutaneous lesions

✍ Dr. Stephen M. Waldow; Rocco V. Lobraico; Irmgard K. Kohler; Silas Wallk; Helen 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 455 KB 👁 1 views

Photodynamic therapy, employing either hematoporphyrin derivative or dihematoporphyrin ether as the photosensitizer and an argon-pumped tunable dye laser as the activating light source, was used to treat ten patients who had primary or recurrent basal or squamous cell carcinoma or infiltrating ducta

Photodynamic therapy using mTHPC for mal

Photodynamic therapy using mTHPC for malignant disease in the oral cavity

✍ Kathleen F.M. Fan; Colin Hopper; Paul M. Speight; Giovanni A. Buonaccorsi; Steph 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 428 KB 👁 1 views

Photodynamic therapy (PDT) produces local tumor necrosis, on activation of a previously administered sensitizer with non-thermal light of an appropriate wavelength. It is attractive for treating tumors of the mouth as tissue healing is particularly good. We describe the use of the photosensitizing a

Quinacrine in the management of malignan

Quinacrine in the management of malignant pleural effusion

✍ S. A. Taylor; N. S. Hooton; A. M. Macarthur 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB 👁 2 views

## Abstract Twenty-five patients with malignant pleural effusion were treated with a single intrapleural dose of Quinacrine. Eighteen patients (72 per cent) had a significant response, with no reaccumulation of fluid for at least 2 months following treatment up to a maximum of 18 months in 2 patien

Intracavitary therapy with bleomycin for

Intracavitary therapy with bleomycin for the treatment of malignant pleural effusions

✍ M. J. Ostrowski 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 544 KB

This paper briefly reviews the incidence of malignant pleural effusions (MPE) and the measures that have been used to treat this condition. The role of intracavitary bleomycin in controlling MPE, the doses used, and morbidity associated with its use are reviewed in depth with reference to multicente

Experimental grounds for using chlorin ρ

Experimental grounds for using chlorin ρ6 in the photodynamic therapy of malignant tumors

✍ G.A. Kostenich; I.N. Zhuravkin; E.A. Zhavrid 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 684 KB

The toxicity, pharmacokinetics and antitumour effect of chlorin e6 after light irradiation were studied. The LD50 value of chlorin e6 in C3H mice is 189 +/- 9 mg kg-1 and in Wistar white rats is 113 +/- 18 mg kg-1 14 days after intraperitoneal injection. The concentration of chlorin e6 in blood, liv