Use of pharmacogenetics in bioequivalence studies to reduce sample size: an example with mirtazapine and CYP2D6

The use of effect sizes to characterize

The use of effect sizes to characterize the nature of cognitive change in psychopharmacological studies: an example with scopolamine

✍ Amy Fredrickson; Peter J. Snyder; Jennifer Cromer; Elizabeth Thomas; Matthew Lew 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

## Abstract Drug induced cognitive change is generally investigated using small sample sizes. In terms of null hypothesis significance testing (NHST) this can render a meaningful change non‐significant, as a result of insufficient power in the statistical model. NHST leads to ‘all or none’ thinking