Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules: Results of a multicenter study
✍ Scribed by P. G. Natali; M. Mottolese; R. Perrone Donnorso; R. Buffa; G. Bussolati; G. Coggi; G. Corradi; L. Coscia-Porrazzi; M. Ferretti; E. Rondanelli; M. Castagna; A. Vecchione; G. A. Siccardi
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- French
- Weight
- 497 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Fine-needle aspiration (FNA) cytology is being increasingly employed in conjunction with physical examination and mammography in the pre-surgical diagnosis of breast nodules. In the present study, we have submitted to multicenter validation an immunocytochemical test which employs monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) for the diagnosis of breast cancer. The results of this analysis, which has evaluated 846 F N h , show that the immunological test has a sensitivity of 88.62%, a specificity of 97.9% and an accuracy of 92.4%. The predictive vake of a positive and a negative finding were 98.4% and 85.57% respectively. Comparison between the cytological and immunocytochemical diagnosis displayed a higher sensitivity, accuracy and predictive value of a negative result with the latter method (p < 0.01). Our findings clearly indicate that immunocytochemical methods can complement and improve the diagnostic accuracy of FNA cytology of breast nodules.