Use of molecule imprinting–chemiluminescence method for the determination of tamoxifen in breast cancer sufferers' urine

✍ Scribed by Fei Nie; Jiuru Lu; Yunhua He; Jianxiu Du

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 116 KB
• Volume: 20
• Category: Article
• ISSN: 1522-7235
• DOI: 10.1002/bio.837

✦ Synopsis

Abstract

The reaction between soluble Mn(IV) and tamoxifen can produce chemiluminescence and formaldehyde can enhance this chemiluminescence reaction. A tamoxifen molecular imprinted polymer (MIP) was synthesized and its adsorption selectivity to tamoxifen in aqueous solution was evaluated. Using a synthesized tamoxifen MIP as the recognition material and a soluble Mn(IV)–formaldehyde–tamoxifen chemiluminesence system as the detection system, a new molecule imprinting–chemiluminesence method of determination of tamoxifen was established. The response range of this method was 1.0 × 10^−7^–6.0 × 10^−6^ g/mL, with a linear correlation coefficient of 0.997. The detection limit was 4 × 10^−8^ g/mL. The relative standard deviation for 5.0 × 10^−7^ g/mL tamoxifen solution was 4.1% (n = 9). Copyright © 2005 John Wiley & Sons, Ltd.