Use of liquid chromatography-nuclear magnetic resonance spectroscopy for the identification of impurities in drug substances

Identification of impurities in acarbose

Identification of impurities in acarbose by using an integrated liquid chromatography-nuclear magnetic resonance and liquid chromatography-mass spectrometry approach

✍ Predrag Novak; Mario Cindrić; Predrag Tepeš; Snježana Dragojević; Marina Ilijaš; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 817 KB

## Abstract The usefulness of applying an integrated LC‐NMR and LC‐MS approach to acarbose bulk drug impurity profiling is demonstrated. LC‐MS and LC‐NMR methodologies were employed for the online separation and structural elucidation of a final drug product. Combining data provided by the stop‐flo

The use of liquid chromatography combine

The use of liquid chromatography combined with a quadrupole time-of-flight analyser for the identification of trace impurities in drug substance

✍ Christine Eckers; Neville Haskins; James Langridge 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB 👁 3 views

Cone voltage (volt) 32 32 32 32 Scan time (min) 0.9 1.0 0.9 0.9 Inter scan time (s) 0.1 0.1 0.1 0.1 Start time (min) 8.13 13.03 13.

Isolation of circulating metabolites in

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy

✍ Hong Kim; Wenqing Feng; Tze-Ming Chan; Diane Rindgen; Matthew Bryant; Kathleen A 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB 👁 3 views

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy One of the major components of modern drug discovery is the structu

Identification of two isomeric meroterpe

Identification of two isomeric meroterpenoid naphthoquinones from Cordia linnaei by liquid chromatography–mass spectrometry and liquid chromatography–nuclear magnetic resonance spectroscopy

✍ Jean-Robert Ioset; Jean-Luc Wolfender; Andrew Marston; Mahabir P. Gupta; Profess 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB 👁 2 views

The structures of two meroterpenoid naphthoquinones have been elucidated in a fraction of the dichloromethane extract from Cordia linnaei Stearn (Boraginaceae). These naphthoquinones were shown to be closely related structural isomers not separable by preparative chromatographic methods. High perfor

Characterization of Metabolites in Intac

Characterization of Metabolites in IntactStreptomyces citricolorCulture Supernatants Using High-Resolution Nuclear Magnetic Resonance and Directly Coupled High-Pressure Liquid Chromatography–Nuclear Magnetic Resonance Spectroscopy

✍ Catharina B.L. Abel; John C. Lindon; David Noble; Brian A.M. Rudd; Philip J. Sid 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 178 KB

Use of proton nuclear magnetic resonance

Use of proton nuclear magnetic resonance spectroscopy of plasma in screening for malignant disease

✍ Shigeki Ono; Fuminori Moriyasu; Motoshige Nabeshima; Kozo Kajimura; Yukitaka Yam 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 707 KB

In 1986, narrow plasma proton nuclear magnetic resonance (NMR) methyl and methylene line widths were reported to be associated with malignant disease, but more recent studies have not confirmed this relationship. The authors analyzed 106 plasma samples from healthy control subjects and patients with