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Use of letrozole as a chemopreventive agent in aromatase overexpressing transgenic mice

✍ Scribed by Roopa Luthra; Nameer Kirma; Jeremy Jones; Rajeshwar Rao Tekmal


Book ID
117668631
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
290 KB
Volume
86
Category
Article
ISSN
0960-0760

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## Abstract A protective effect of sphingolipids on colorectal cancer (CRC) has been reported in certain mouse strains. It is unknown if sphingolipids are protective in a __p53__ deficiency mouse model of CRC. This study investigated the effect of sphingomyelin (SM) on intestinal sphingomyelinase (