𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Use of human hepatocyte cultures for drug metabolism studies

✍ Scribed by André Guillouzo; Fabrice Morel; Olivier Fardel; Bernard Meunier

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
730 KB
Volume
82
Category
Article
ISSN
0300-483X

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Predicting drug interactions using cultu
Predicting drug interactions using cultured human hepatocytes
✍ Kenneth S. Lown; Paul B. Watkins 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 406 KB

HEPATOLOGY ## 396 HEPATOLOGY Elsewhere between beneficial and harmful cytokines or whether some cytokines are beneficial in low amounts but toxic at high levels. Studies addressing these types of questions will provide new insights into the liver injury and clinical manifestations of alcoholic he

Chiral aspects of metabolism of antiinfl
Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes
✍ Lenka Skálová; Radim Král; Barbora Szotáková; Yogeeta N. Babú; Lydiane Pichard-G 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB 👁 1 views

## Abstract The metabolism of the nonsteroidal antiinflammatory drug flobufen, 4‐(2′,4′‐difluorobiphenyl‐4‐yl)‐2‐methyl‐4‐oxobutanoic acid, was studied in primary cultures of human hepatocytes prepared by two‐step collagenase perfusion of livers from four donors. Racemic flobufen or its individual

Rabbit hepatocytes in primary culture: P
Rabbit hepatocytes in primary culture: Preparation, viability and use in studies of propranolol metabolism
✍ Horace E. Walpole; William M. Lee; Thomas Walle; U. Kristina Walle; Michael J. W 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 852 KB

Isolated hepatocyte cultures have become a frequently used model system for investigating drug metabolism. Although rat and hamster hepatocytes are frequently used for this purpose, metabolism in these species differs in many respects from human metabolism. A species with a metabolism more closely r

Effects of hepatocyte growth factor on t
Effects of hepatocyte growth factor on the growth and metabolism of human hepatocytes in primary culture
✍ María José Gómez-Lechón; José Castelli; Isabel Guillén; Enrique o'Connor; Toshik 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 836 KB

The effect of recombinant human hepatocyte growth factor (h-rHGF), a potent mitogen for hepatocytes, was investigated in primary cultures of human hepatocytes. Here, we describe a series of experiments to investigate the kinetics of its mitogenic action, as well as its metabolic effects on cultured