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Use of human-derived cell lines for the investigation of dietary factors which affect DNA stability

✍ Scribed by Heike Winter; Bettina Grasl-Kraupp; Rolf Schulte-Hermann; Michael Grusch; Wolfgang Mikulits; Veronika Ehrlich; Siegfried Knasmüller


Publisher
BioMed Central
Year
2007
Tongue
English
Weight
72 KB
Volume
7
Category
Article
ISSN
1471-2210

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✍ Ann C. Williams; Jayne C. Miller; Tracey Collard; Sara J. Browne; Robert F. Newb 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB 👁 2 views

We examined the effect of loss of wild type TP53 activity on the chromosomal stability of a human colonic adenoma derived cell line (designated AA/C1) by studying transfected variants which express different TP53 mutations. Using gross chromosomal aberrations as a measure of instability, we studied