✦ LIBER ✦

Use of gel filtration in the preparation of biological fluids for magnetic resonance spectroscopy

✍ Scribed by David W. Hoffman; Ronald A. Venters; Suzanne F. Shedd; Leonard D. Spicer

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 388 KB
Volume: 13
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910130319

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Analysis of biological fluids by proton magnetic resonance spectroscopy is often complicated by dynamic range problems created from the large water resonance. Gel filtration chromatography is found to be a simple and nondestructive method for exchanging D~2~O for H~2~O and for removing low molecular weight molecules from both plasma and urine, significantly improving subsequent one‐ and two‐dimensional MRS spectra.

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