𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Use of fractal geometry to determine effects of surface morphology on drug dissolution

✍ Scribed by Dina Farin; David Avnir

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
426 KB
Volume
81
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

We extend and modify the Noyes-Whitney equation and the Hixon-Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, Dm of the effective surface which undergoes dissolution. Effects of changes in D, on the dissolution rate are identified and explained.

πŸ“œ SIMILAR VOLUMES

The Effect of Overlap between Monomers o
The Effect of Overlap between Monomers on the Determination of Fractal Cluster Morphology
✍ C. Oh; C.M. Sorensen πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 244 KB

for a variety of colloidal and aerocolloidal aggregates includ-Diffusion limited cluster aggregate (DLCA) morphology is studing soot. Until recently, however, the prefactor has been ied as a function of monomeric particle overlap for finite sized ignored. Its accepted importance has been increasing

Agglomerate parameters and fractal dimen
Agglomerate parameters and fractal dimension of soot using light scatteringβ€”effects on surface growth
✍ T.T. Charalampopoulos; H. Chang πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 745 KB

Measured scattering, extinction coefficients, and dissymmetry ratios at 0.488/xm from a premixed propane-oxygen flame with a fuel equivalence ratio of ~b o = 1.8 are combined with the scattering and extinction model for agglomerates to determine each of the following: primary particle diameter, numb