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Use of Dynamic Combinatorial Chemistry for the Identification of Covalently Appended Residues that Stabilize Oligonucleotide Complexes

✍ Scribed by Anthony Bugaut; Jean-Jacques Toulmé; Bernard Rayner


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
122 KB
Volume
43
Category
Article
ISSN
0044-8249

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## Abstract We describe the use of dynamic combinatorial chemistry (DCC) to identify ligands for the stem‐loop structure located at the exon 10‐5′‐intron junction of Tau pre‐mRNA, which is involved in the onset of several tauopathies including frontotemporal dementia with Parkinsonism linked to chr