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Use of deuterium labelling in mechanistic studies of the metabolic chiral inversion of ibuprofen

✍ Scribed by T.A. Baillie; W.J. Adams; D.G. Kaiser; L.S. Olanoff; G.W. Halstead; H. Harpootlian; G. Van Giessen

Publisher
Elsevier Science
Year
1988
Weight
80 KB
Volume
39
Category
Article
ISSN
0883-2889

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Stereoselective syntheses of deuterium labelled marmesins; valuable metabolic probes for mechanistic studies in furanocoumarin biosynthesis
✍ Volker Stanjek; Martin Miksch; Wilhelm Boland πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 906 KB

Stereoselective syntheses of deuterium labelled marmesins 3a-3e as metabolic probes for biosynthetic studies are described. Starting from iodo-umbelliferone (5), the title compounds were readily available by copper catalysed alkylation-cyclisation and subsequent transfer-hydrogenation of the resulti