✦ LIBER ✦

Use of concurrent chemotherapy, accelerated fractionation radiation, and surgery for patients with esophageal carcinoma

✍ Scribed by David J. Adelstein; Thomas W. Rice; Mark Becker; Marjorie A. Larto; Thomas J. Kirby; Anuradha Koka; Melvin Tefft; Gregory Zuccaro

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 123 KB
Volume: 80
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19970915)80:6<1011::aid-cncr2>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

beginning on Day 1 and Day 21, concurrent with a split course of accelerated fractionation radiation (1.5 grays [Gy] twice daily, to a total dose of 45 Gy). All 1 Department of Hematology and Medical Onpatients were subsequently referred for surgical resection. A single, identical postcology, Cleveland Clinic Foundation, Cleveland, operative course of chemotherapy and 24 Gy accelerated fractionation radiation Ohio.

was planned for patients with residual tumor at surgery. 2 Department of Thoracic and Cardiovascular

RESULTS.

Seventy-four patients were entered on this study; 72 patients were con-Surgery, Cleveland Clinic Foundation, Cleveland, sidered eligible and evaluable. Induction toxicity included nausea (85%), increased Ohio.

dysphagia (90%), neutropenia (õ1000/mm 3 ) (43%), thrombocytopenia (õ20,000/

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