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Use of complex DNA and antibody microarrays as tools in functional analyses

✍ Scribed by Andrea Bauer; Boris Beckmann; Christian Busold; Ole Brandt; Wlad Kusnezow; Janne Pullat; Verena Aign; Kurt Fellenberg; Robert Fleischer; Anette Jacob; Marcus Frohme; Jörg D. Hoheisel

Publisher: Hindawi Publishing Corporation
Year: 2003
Tongue: English
Weight: 224 KB
Volume: 4
Category: Article
ISSN: 1531-6912
DOI: 10.1002/cfg.320

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✦ Synopsis

While the deciphering of basic sequence information on a genomic scale is yielding complete genomic sequences in ever-shorter intervals, experimental procedures for elucidating the cellular effects and consequences of the DNA-encoded information become critical for further analyses. In recent years, DNA microarray technology has emerged as a prime candidate for the performance of many such functional assays. Technically, array technology has come a long way since its conception some 15 years ago, initially designed as a means for large-scale mapping and sequencing.

The basic arrangement, however, could be adapted readily to serve eventually as an analytical tool in a large variety of applications. On their own or in combination with other methods, microarrays open up many new avenues of functional analysis.

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