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Use of combinatorial peptide libraries for T-cell epitope mapping

✍ Scribed by Mireia Sospedra; Clemencia Pinilla; Roland Martin

Book ID
117702221
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
682 KB
Volume
29
Category
Article
ISSN
1046-2023

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cells recognize short antigenic peptides bound to major histocompatibility complex (MHC) molecules. Engagement of the T-cell receptor (TCR) determines not only the fate of the cell during thymic selection, but also its survival in the periphery and, eventually, the extent of functional activation 1