AB/HIA is a "soft" filter for identifying compounds with poor intestinal membrane permeability. The analyzed data set included over 1000 drug-like compounds with experimental human intestinal absorption (HIA) values. A sequence of recursive partitioning analyses based on multiple physicochemical and
Use of Classification Regression Tree in Predicting Oral Absorption in Humans.
β Scribed by Jane P. F. Bai; Andrey Utis; Gordon Crippen; Han-Dan He; Volker Fischer; Robert Tullman; He-Qun Yin; Cheng-Pang Hsu; Lan Jiang; Kin-Kai Hwang
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Early prediction of human intestinal absorption is important in selection of potential orally administered drugs. Various computational models for prediction of the fraction of dose absorbed, __Fa__, have been developed. In 1989, a sigmoidal relationship between __Fa__ and drug absorpti