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Use of chitosan as a biomaterial: Studies on its safety and hemostatic potential

✍ Scribed by Rao, S. Bhaskara ;Sharma, Chandra P.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 247 KB
Volume: 34
Category: Article
ISSN: 0021-9304
DOI: 10.1002/(sici)1097-4636(199701)34:1<21::aid-jbm4>3.0.co;2-p

No coin nor oath required. For personal study only.

✦ Synopsis

Chitosan, a mucopolysaccharide of marine origin, was stud-aldehyde with a physiologic pH retained the maximum tenied for its safety and hemostatic potential. Its surface was sile strength of chitosan. In vivo toxicity tests indicated that treated with glutaraldehyde, carbodiimide, and plasma glow it is nontoxic, and the sterilized films were free of pyrogen. discharge to elicit effects of enzyme degradation. Of the seven Coagulation and hemagglutination tests showed that the heenzymes used, leucine amino peptidase caused maximum mostatic mechanism of chitosan seems to be independent degradation. Autoclaving appeared to be an ideal sterilizing of the classical coagulation cascade and appears to be an method as it caused least decrease in tensile strength and interaction between the cell membrane of erythrocytes and effected a negligible rate of hemolysis. Sterilizing with glutar-chitosan.

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