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Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities

✍ Scribed by Matthias Wölfl; Jürgen Kuball; Matthias Eyrich; Paul G. Schlegel; Philip D. Greenberg


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
335 KB
Volume
73A
Category
Article
ISSN
0196-4763

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## Abstract Spontaneous tumors frequently express antigens that can be recognized by the immune system but nevertheless manage to evade immune surveillance. To better understand the mechanism of evasion, we followed CD8 and CD4 T cells reacting against a subcutaneously growing tumor, modified to ex