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Use of Bone Marrow Chimeras to Identify Cell Targets in the Immune System for the Actions of Chemicals

✍ Scribed by THOMAS A. GASIEWICZ; T. SCOTT THURMOND; J. ERIN STAPLES; FRANCIS G. MURANTE; ALLEN E. SILVERSTONE

Book ID
111396657
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
152 KB
Volume
919
Category
Article
ISSN
0890-6564

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The mechanism of transplantation tolerance in total lymphoid irradiation (TLI)-induced semiallogeneic bone marrow chimeras without clinical evidence of graft-versus-host disease (GVHD) was investigated using the technique of surgical parabiosis. When held in parabiosis with normal BALB/c mice, BALB/