Use of asymmetric propargyl dicobalt hexacarbonyl complexes in organic synthesis: Access to enantiomerically pure α-hydroxy acid derivatives

✍ Scribed by Juan M. Betancort; Carmen Ma Rodríguez; Víctor S. Martín

• Book ID: 104260307
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 258 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)02170-4

✦ Synopsis

The trapping under different conditions of the carbocation generated by acid treatment of chiral Co2(CO)6complexed propargylic secondary alcohols permitted access to either diastereoisomer at the propargylic center. Further chemical manipulations provided either enantiomer of enantiomerically pure 1,2-difunctionalized molecules such as 1,2-diols, ct-hydroxy-aldehydes or ¢t-hydroxy-acids.