Use of an intravascular T1 contrast agent to improve MR cine myocardial-blood pool definition in man
✍ Scribed by Arthur E. Stillman; Norbert Wilke; Michael Jerosch-Herold
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 619 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
The feasibility of improving myocardial/blood pool contrast in MR cine images through use of an intravascular contrast agent (Ferumoxtran, Advanced Magnetics, Inc., Cambridge, MA) was tested in four subjects. The contrast‐to‐noise ratio (CNR) demonstrated a trend toward improvement in the short axis and improved significantly in the long axis cine by an average of 128% (P < .05). Image intensity gradients at the myocardial/blood pool interface increased significantly in both the short and long axis (P < .01). It is expected that larger image intensity gradients at the endocardial border should improve the capabilities of automated segmentation algorithms, reducing the uncertainty and need for manual editing.