Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial

Determination of RSD921 in human plasma

Determination of RSD921 in human plasma by high-performance liquid chromatography–tandem mass spectrometry using tri-deuterated RSD921 as internal standard: application to a phase I clinical trial

✍ Wellington Ribeiro; Demian R Ifa; Gaetano Corso; John Salmon; Leonardo A. Moraes 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB

## Abstract A fast, sensitive and specific method is presented for the quantification of RSD921 in human plasma by liquid chromatography coupled with tandem mass spectrometry using tri‐deuterated RSD921 (3d‐RSD921) as an internal standard. A single‐step liquid/liquid extraction was performed with d