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Use of a spheroid model to study chemotherapy and radiation effects on proliferating and hypoxic tumor cell populations

✍ Scribed by D. Moore; E. Zeman; G. Massenburg; B. Rouse; J. Raleigh

Book ID
119054266
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
324 KB
Volume
45
Category
Article
ISSN
0090-8258

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## Abstract The growth of multicellular tumor spheroids, MTSs, from squamous carcinoma line MDA 886Ln was inhibited by β‐all‐trans retinoic acid (RA). Inhibition occurred within 3 to 5 days of treatment, and MTS size then remained static for up to 2 weeks. Although their growth stopped, 10‐day‐trea