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Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz

✍ Scribed by Marco Siccardi, Adeniyi Olagunju, Kay Seden, Farid Ebrahimjee…


Book ID
120802999
Publisher
Springer (Biomed Central Ltd.)
Year
2013
Tongue
English
Weight
257 KB
Volume
1
Category
Article
ISSN
2193-9616

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Background: Rivaroxaban is an oral Factor Xa inhibitor. The primary objective of this communication was to quantitatively predict changes in rivaroxaban exposure when individuals with varying degrees of renal impairment are co-administered with another drug that is both a P-gp and a moderate CYP3A4