Use of a linear function of several variables in simplex optimization as a procedure for assessing analytical versatility in FIA
✍ Scribed by J. Alonso; J. Bartroli; M. del Valle; A. A. S. C. Machado; L. M. A. Ribeiro
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 396 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0886-9383
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✦ Synopsis
A linear response function RF = CH RH + CT (1 -RT) (RH = peak height, used as a measure of 'sensitivity', and RT = analysis time, 1 -RT used as a measure of sampling rate) was used to optimize a FIA system for the determination of nitrite in water with respect to four experimental parameters (two tube lengths and two flow rates) by a Simplex procedure. The weights CH and CT placed on Rti and RT were systematically varied to cover their allowed range and the system obtained in each optimization experiment was implemented and evaluated by determining the following analytical parameters: reproducibility, limit of detection and sampling rate. It was found that these depend very markedly on the weights used in the response function. Hence the use of a linear function for optimization provides a useful procedure for assessing the versatility of the experimental technique and for choosing the systems for its implementation in different practica1 situations.