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Use of a combination of the RDC method and NOESY NMR spectroscopy to determine the structure of Alzheimer’s amyloid Aβ10–35peptide in solution and in SDS micelles

✍ Scribed by Usachev, Konstantin S.; Filippov, Andrey V.; Antzutkin, Oleg N.; Klochkov, Vladimir V.


Book ID
121602441
Publisher
Springer
Year
2013
Tongue
English
Weight
650 KB
Volume
42
Category
Article
ISSN
1432-1017

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## Abstract The β‐amyloid (Aβ) is the major peptide constituent of neuritic plaques in Alzheimer's disease (AD) and its aggregation is believed to play a central role in the pathogenesis of the disease. Naturally occurring mutations resulting in changes in the Aβ sequence (pos. 21‐23) are associate