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Use of a Biosensor with Surface Plasmon Resonance Detection for the Determination of Binding Constants: Measurement of Interleukin-6 Binding to the Soluble Interleukin-6 Receptor

✍ Scribed by Ward, Larry D.; Howlett, Geoffrey J.; Hammacher, Annet; Weinstock, Janet; Yasukawa, Kiyoshi; Simpson, Richard J.; Winzor, Donald J.


Book ID
127040065
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
883 KB
Volume
34
Category
Article
ISSN
0006-2960

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## Abstract A surface plasmon resonance (SPR) biosensor was used to study the interaction of human interleukin‐5 (hIL5) with its receptor. IL5 is a major growth factor in the production and activation of eosinophilis. The receptor for IL5 is composed of two subunits, Ξ± and Ξ². The Ξ± subunit provides