𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Use of a biomimetic strategy to engineer bone

✍ Scribed by Holy, C. E. ;Fialkov, J. A. ;Davies, J. E. ;Shoichet, M. S.

Book ID
102292386
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
199 KB
Volume
65A
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

Engineering trabecular‐like, three‐dimensional bone tissue throughout biodegradable polymer scaffolds is a significant challenge. Using a novel processing technique, we have created a biodegradable scaffold with geometry similar to that of trabecular bone. When seeded with bone‐marrow cells, new bone tissue, the geometry of which reflected that of the scaffold, was evident throughout the scaffold volume and to a depth of 10 mm. Preseeded scaffolds implanted in non‐healing rabbit segmental bone defects allowed new functional bone formation and bony union to be achieved throughout the defects within 8 weeks. This marks the first report of successful three‐dimensional bone‐tissue engineering repair using autologous marrow cells without the use of supplementary growth factors. We attribute our success to the novel scaffold morphology. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 65A: 447–453, 2003

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