Use of 1-Methyl-Pyrrolidone as a Solubilizing Agent for Determining the Uptake of Poorly Soluble Drugs
โ Scribed by Antje S. Uch; Ulrich Hesse; Jennifer B. Dressman
- Book ID
- 110309161
- Publisher
- Springer US
- Year
- 1999
- Tongue
- English
- Weight
- 550 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The challenge of designing a delayed-release oral dosage form is significantly increased when the drug substance is poorly water soluble. This manuscript describes the design and characterization of a novel controlled-release film-coated tablet for the pH-triggered delayed and complete release of po
The objective of this work was to demonstrate that the incorporation of sulfobutylether-beta-cyclodextrin, (SBE)(7M)-beta-CD, results in the complete and sustained release of a sparingly water-soluble drug, prednisolone (PDL) from controlled porosity-osmotic pump pellets (CP-OPP). PDL and CD were pr
Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB