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Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine

✍ Scribed by Pierre Paul Van Bogaert; François Pittoors


Book ID
113584274
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
647 KB
Volume
478
Category
Article
ISSN
0014-2999

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Block of the cardiac pacemaker current (
✍ D. DiFrancesco; F. Porciatti; D. Janigro; G. Maccaferri; M. Mangoni; T. Tritella 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 508 KB

We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the