Ursodeoxycholic acid (UDCA) feeding aggravates liver injury in bile duct-ligated and MDR2 kockout mice
β Scribed by P. Fickert; G. Zollner; A. Fuchsbichler; C. Stumptner; F. Lammert; K. Zaltloukal; H. Denk; M. Trauner
- Book ID
- 119527500
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 135 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0168-8278
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Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Despite limited benefits, ursodeoxycholic acid (UDCA) is the only Food and Drug Administration-approved treatment for cholestatic disorders. Retinoic acid (RA) is a ligand for nuclear receptors that modulate bi