Ursodeoxycholic Acid Suppresses Extent of Lipid Peroxidation in Diseased Liver in Experimental Cholestatic Liver Disease
โ Scribed by Predrag Ljubuncic; Zahava Tanne; Arieh Bomzon
- Book ID
- 110226399
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 89 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0163-2116
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๐ SIMILAR VOLUMES
The precise role of lipid peroxidation in the pathogenesis of alcoholic liver disease is still being debated. To explore the issue, this study was undertaken to investigate the status of lipid peroxidation, antioxidants and prooxidants at two discrete stages of experimental alcoholic liver disease.
Beneficial effects of ursodeoxycholic acid in chronic cholestatic liver diseases have been attributed to displacement of hydrophobic bile acids from the endogenous bile acid pool. To test this hypothesis, we determined pool sizes, fractional turnover rates, synthesis/input rates and serum levels of
from their site of origin to attack distant targets and form Lipid peroxidation is an autocatalytic mechanism leading to covalent links with various molecules (adducts). 2 Different oxidative destruction of cellular membranes. The deleterious cytotoxic effects of MDA and HNE adduct formation have co