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Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation

โœ Scribed by In.H. Park; Mi K. Kim; Seung U. Kim


Book ID
116297013
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
802 KB
Volume
377
Category
Article
ISSN
0006-291X

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Background. Neuroblastoma (NBL) is one of the most common solid malignancies in childhood and is derived from the sympathetic precursor cells. Although p53, a tumor suppressor, has been reported to be rarely mutated in NBLs, it is sequestered abnormally in the cytoplasm of the NBL cell. The mechanis