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Ursodeoxycholic acid inhibits tumor development during both AOM-induced colon tumor initiation and progression

✍ Scribed by Wali, Ramesh K.; Stoiber, Debra M.; Hart, John A.; Sitrin, Michael D.; Brasitus, Thomas A.; Bissonnette, Marc


Book ID
124142763
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
181 KB
Volume
120
Category
Article
ISSN
0016-5085

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## Abstract We evaluated RS5444, a thiazolidinedione high affinity PPARΞ³ agonist, for the ability to inhibit colon carcinogenesis in azoxymethane (AOM)‐treated mice. In our initial experiment, mice were treated with RS5444 during AOM treatment, and the drug was withdrawn 12 weeks after the last inj