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Ursodeoxycholic acid inhibits the induction of nitric oxide synthase

✍ Scribed by Yoshiyuki Hattori; Yasuyuki Murakami; Sachiko Hattori; Hisamoto Kuroda; Kikuo Kasai; Shin-Ichi Shimoda

Book ID: 115890923
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 408 KB
Volume: 300
Category: Article
ISSN: 0014-2999
DOI: 10.1016/0014-2999(96)00012-x

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## Abstract Free radical nitric oxide (NO), generated by inducible nitric oxide synthase (iNOS) in astrocytes and macrophages, has been implicated in CNS inflammatory disorders such as multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). Mycophenolic acid (MPA),